Department of Chemistry & Biochemistry

 Office:  C410 BNSN

 Office Phone:  801-422-8171

 Email:  mbandrus@chem.byu.edu

Education

BS, Brigham Young University (1986)

Ph.D., University of Utah (1986-1991)

NIH Postdoctoral Fellow, Harvard University (1991-1993)

Assistant Professor, Purdue University (1993-1997)

NSF Career Award (1995)

Procter & Gamble University Exploratory Research Award (1996)

Research Interests

 Synthetic construction of agents which are selective inhibitors of signaling pathways in cancer cells, including multi-drug resistance via Pgp 170, and heat shock protein Hsp90.  Natural products targets once obtained are then modified to study their structural relationship with biological activity.

Student Involvement/Requirements

 I will train as many as four undergraduates in my lab.  The students will work with me as well as other undergraduates, graduate students, and post doctoral students.  I begin taking undergraduates in their junior year.  These students must meet the following requirements in order to be considered for work in my lab:

1.) Organic Chem 351, 352, 353

2.)  Resume

 A minimum of a 2 semester commitment is required and those students with a willingness to work will be more attractive candidates than others.  The work is publication oriented and undergraduates do appear on all publications they are involved in.  The source of funding is NIH and the American Cancer Society.

Publications

 Andrus, M.B., “Polyene Multi-Drug Resistance Reversal Agents,” Current Opinion in Drug Discovery & Development, 7(6), 823-831 (2004).

Andrus, M.B., Hicken, E.J., Stephens, J.C., “Phase-Transfer Catalyzed Asymmetric Glycolate Alkylation,” Org. Lett. 6(13), 2289-2292 (2004).

Sauna, Z.E., Andrus, M.B., Turner, T.M., Ambudkar, S.V., “The Biochemical Basis of Polyvalency as a Strategy to enhance the Efficacy of P-Glycoprotein (ABCB1) Modulators: Stipiamide Homodimers Separated with Spacers of Defined Length Reverse Drug Efflux with Greater Efficiency,” Biochemistry, 43, 2262-2271 (2004).